Problem
You may think the biggest challenge for Humanity is to find solutions against climate change and pollution.
Know that there is a phenomenon whose apocalyptic consequences for our species will be 1000 times more devastating than climate change!
This phenomenon is the ageing of Humanity.
Imagine a world where 8 out of 10 people are over 80 yo.
Imagine a world where these seniors would be suffering from multiple diseases:
cancers, diabetes, liver failure, hypertension, atherosclerosis and heart attack, stroke, Parkinson, kidney failure and incontinence, lung deficiency, Alzheimer, sarcopenia, dementia, cataracts, malnutrition, rheumatoid arthritis, osteoporosis, immune system failure and infections ...
The incidence of all of these diseases increases exponentially with age.
This apocalyptic world is coming. In 2050, the old people will outnumber the active people in most Western developed countries. The developing countries are also affected by the ageing of their populations, they follow the same path as the Western countries.
Advances in medicine but also in agriculture, supply chain and logistics have enabled us to overcome infant mortality and increase longevity. But longevity has a cost, beyond 50 years old, appear many diseases caused by ageing (while ageing starts at your conception, it is well fought by your physiology ... until it fails).
In short, the longer is your life expectancy, the more old (senescent) dysfunctional cells accumulate in your body. Senescent cells cause your tissues and organs to malfunction... driving you to certain death!
The main factors accelerating your ageing:
Physical inactivity, poor quality and quantity of sleep, exposure to violent or chronic stress, chronic consumption of tobacco, alcohol, drugs and xenobiotics, chronic exposure to environmental pollution, ultra-processed and junk food.
Current solutions and why they are unsatisfactory
You can to some extent try to change your lifestyle (work out, audit your quality of sleep, change your diet in favour of a healthy diet, stop smoking, stop drinking alcohol and other toxic substances), but it will be more difficult for you to overcome an environment in which you have to live. And you can't fight your genetics with simple changes in your lifestyle.
Modern medicine is based on specialities treating independently each disease. This approach requires many specialities: endocrinology diabetology, gastroenterology, neurology, rheumatology, pneumology, cardiology, psychiatry, nephrology, oncology .... .
Each specialist will try to limit the symptomatic consequences of the cause of causes which is ageing. Medicine based on specialists also leads to a lack of communication between the specialities. When geriatricians enter the scene, their holistic or systemic approach is crucial, but it is far too late.
Ideal Solution
We need to consider ageing as a disease, the mother of all diseases, the cause of causes!
We want a medicine able to slow down ageing or stop it as soon as possible, or even achieve a certain level of rejuvenation at the cellular and molecular levels.
About a decade ago, scientists identified the 9 cellular and molecular reasons for ageing. The rate of ageing is controlled by genetic pathways and biochemical processes in cells. We age, because our cells age and the body systems start to deteriorate.
“The Hallmarks of Aging”
For each of them, there is a specific approach to address the impact on our body's decline. However, while for every one of the hallmarks, theoretical interventions exist, practical interventions are not ready for all of them. Therefore, there is a free space of opportunities for startup companies to bring us new anti-ageing solutions.
What needs to be done to fight ageing?
Partial Reprogramming: Imagine reversing the effects of aging at the cellular level.
Stem Cell Therapy: Beyond traditional applications, the use of exosomes presents a new frontier in regenerative medicine, offering the promise of tissue repair and regeneration.
Senotherapeutics: Targeting senescent cells to reduce inflammation and improve tissue function, paving the way for a healthier aging process.
Metabolic Rejuvenation: Drugs that mimic the effects of calorie restriction could be the key to longevity.
But that's not all. The longevity industry is also making strides in diagnostics, treatments, and wellness, with innovations like whole-body scans, exosome therapy, and longevity supplements reshaping our approach to health and aging.
I recommend you the article by Maud Pasturaud, reviewing the longevity space: LINK
From Tech Startups to the Frontiers of Longevity: The Gabriel Cian Odyssey
In a world where the boundaries of technology and human potential are constantly being pushed, there are those who not only ride the wave of innovation but also steer it towards uncharted territories. One such pioneer is Gabriel Cian, a serial entrepreneur whose journey from a rigorous academic background to the zenith of tech entrepreneurship, and now into the longevity space, is nothing short of a modern-day odyssey.
Our latest podcast episode features an exclusive interview with Gabriel, a narrative that unfolds the layers of his life, revealing the resilience, the intellect, and the audacious dreams that have propelled him from his early days in Romania to the prestigious halls of École Polytechnique and beyond.
The Genesis of a Tech Virtuoso
Gabriel's story begins in Bucharest, in a family where academic excellence was not just encouraged but demanded. His childhood, marked by a competitive spirit and a passion for mathematics and physics, set the stage for a future where pushing limits would become second nature. Despite the pressures of a demanding upbringing, Gabriel found his calling in the world of technology and business, even dabbling in entrepreneurial ventures as a teenager.
The Leap into Entrepreneurship
The podcast delves into Gabriel's transition from a top-tier engineering student to a tech entrepreneur, a path less traveled by his peers. His early ventures, born out of a partnership with a friend and the sheer will to create something of his own, laid the foundation for his future successes. Gabriel's narrative is a testament to the power of conviction and the courage to defy norms, even in the face of skepticism from mentors and the military discipline of École Polytechnique.
The Longevity Quest
But what happens when a successful entrepreneur decides to pivot towards a cause as grand as defeating aging? Gabriel's latest venture is not just a business; it's a mission to extend human healthspan and challenge the very concept of aging. The podcast paints a vivid picture of Gabriel's vision, his encounter with the burgeoning field of transhumanism, and his ultimate commitment to the longevity space.
A Glimpse into the Future
Listeners will be captivated by Gabriel's insights into the longevity community, his strategic approach to understanding and mapping the ecosystem, and the operational projects that are now coming to fruition. His partnership with Max Kamrani, another brilliant mind in IT engineering, and their co-founding of the "2060" foundation, is a bold step towards a future where aging could be a relic of the past.
Why You Can't Miss This Interview
This podcast is not just an interview; it's a journey through the life of a visionary. It's an exploration of what drives an individual to pursue greatness against all odds. Gabriel's story is a powerful reminder that the future belongs to those who dare to dream big and work tirelessly towards those dreams.
So, if you're intrigued by the intersection of technology, entrepreneurship, and the quest for longevity, if you're inspired by stories of resilience and innovation, or if you're simply looking for a spark to ignite your own ambitions, then this episode is a must-listen.
Join us as we unravel the fascinating tale of Gabriel Cian, a man who's not just living life but redefining it for all of humanity. Tune in to the podcast and be part of a conversation that could very well shape the future of how we live and age.
Don't miss out on this extraordinary narrative. Listen to the full interview and be inspired to think bigger, reach further, and dream bolder.
Books recommended by Garbiel at the end of our discussion
Join us to make this future happen ...
Dr Ari Massoudi - https://www.linkedin.com/in/arimassoudi/